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Medication and Other Effects

All antiepileptic drugs can cause tiredness, cognitive impairment, increase of sleep duration and decrease of the activity level to some degree.

Medication

Side Effects (consult your doctor if you notice the side effects in bold)

Bromide

Acne

 

Lack of energy

Rash

Seizures caused by missing doses of medication

Tiredness / Change of mood or character

Carbamazepine

Aggression

 

Ankle swelling

Blurring of vision

Depression

Diarrhoea

Difficulty with sleeping

Dizziness

Double vision

Drowsiness

Excessive bruising or bleeding tendency

Excitability

Headache

Impotence

Irritability

Nausea

Recurring infections

Skin pallor

Skin rash

Tiredness

Tremor

Unsteadiness when walking

Vomiting

Weight gain

Yellow jaundice / leucopenia

Clobazam

Aggression

 

Blurred vision

Dizziness

Drowsiness

Irritability

Lack of energy

Restlessness

Unsteadiness when walking

Clonazepam

Aggression

 

Depression

Difficulty with concentrating or thinking

Drowsiness

Excitability

Hyperactivity

Irritability

Lethargy

Nausea

Restlessness

Sore throat

Strange or unusual behaviour

Unsteadiness when walking

Worsening seizure frequency

Ethosuximide

Aggression

 

Diarrhoea

Double vision

Drowsiness

Excessive bruising or bleeding tendency

Excitability

Headache

Intermittent favour

Irritability

Joint pains

Nausea / hiccoughs/ loss of appetite 
difficulty with sleeping

Recurring infections

Skin pallor

Skin rash

Slowness of movement

Strange or unusual behaviour

Tremor

Unsteadiness when walking

Vomiting

Felbamate

Aggression

 

Blurred or doubled vision

Depression

Diarrhoea

Difficulty with sleeping

Dizziness

Excitability

Irritability

Nausea

Skin rash

Strange or unusual behaviour

Tiredness

Unsteadiness when walking

Vomiting 
leucopenia / aplastic anemia / hepatic failure 
sometimes life-threatening

Weight loss

Gabapentin

Dizziness

 

Double vision

Drowsiness

Headache

Increasingly frequent seizures

Nasal discharge

Nausea

Tremor

Unsteadiness when walking

Vomiting

Lamotrigine

Depression

 

Difficulty with sleeping

Dizziness

Double vision

Drowsiness

Excessive bruising or bleeding tendency

Headache

Nausea

Recurring infections

Skin pallor

Skin rash (sometimes severe)

Strange or unusual behaviour

Tiredness

Tremor

Vomiting

Levetiracetam

Dizziness

 

Drowsiness

Headache

Recurring infections

Tiredness

Oxcarbazepine

Ankle swelling

 

Diarrhoea

Dizziness

Drowsiness

Hair loss

Headache

Nausea

Skin rash

Tiredness

Vomiting

Weight gain 
hyponatriemia

Phenobarbital

Aggression / change of character and mood, hyperactivity in children

 

Depression

Difficulty with sleeping

Dizziness

Drowsiness

Excessive bruising or bleeding tendency

Excitability

Hyperactivity (in children)

Impotence

Irritability

Joint swelling and pains

Reduced libido

Skin rash

Thickening of tissue in the palms of the hands

Unsteadiness when walking

Phenytoin

Altered menstrual cycle

 

Clumsiness

Depression

Dizziness

Drowsiness

Enlargement of glands

Excessive bruising or bleeding tendency

Excitability

Fever

Headache

Increased hair growth

Irritability

Joint swelling and pains

Loss of feeling in the extremities

Mental confusion

Recurring infections

Reduced effectiveness of oral contraceptives

Reduced limb muscle power

Skin pallor

Skin rash

Swelling or inflammation of the gums

Thickening of facial tissues

Tiredness

Unsteadiness when walking

Yellow jaundice, liver failure

Piracetam

Diarrhoea

 

Difficulty with sleeping

Dizziness

Drowsiness

Indigestion

Nausea

Restlessness

Skin rash

Tremor

Vomiting

Weight gain

Primidone

Aggression

 

Difficulty with concentration or thinking

Difficulty with sleeping

Drowsiness

Excessive bruising or bleeding tendency

Frozen shoulder

Hyperactivity (in children)

Impotence

Mood changes (especially depression)

Recurring fevers

Reduced libido

Skin rash

Thickening of tissue in the palms of the hands

Unsteadiness with walking

Sulthiame

Nausea 
Tachypnoea / hperpnoea / paraesthesia

 

Rapid heartbeat

Restlessness

Tingling

Vomiting

Weight loss

Tiagabine

Confusion

 

Depression

Diarrhoea

Dizziness

Flu-like symptoms

Headaches

Nervousness

Strange or unusual behaviour

Tiredness

Tremor

Unsteadines when walking

Topiramate

Agitation

 

Confusion

Diarrhoea

Dizziness

Double vision

Headache

Nausea

Sleepiness

Tingling

Tremor

Unpredictable mood

Unreliable memory, cognitive impairment

Unsteadiness when walking

Weight loss, loss of appetite

Valproate

Abdominal pain, liver failure, pancreatitis 
sometimes life-threatening

 

Aggression

Difficulty with concentration or thinking

Drowsiness

Excessive bruising or bleeding tendency 
sometimes life-threatening

Fever

Hair loss

Mental confusion

Muscle weakness

Nausea

Recurring infections

Tiredness

Tremor

Vomiting

Weight gain

Yellow jaundice 
Neuronal tube defects in children when taken during pregnancy

Vigabatrin

Aggression

 

Agitation

Confusion

Depression

Diarrhoea

Dizziness

Double vision

Drowsiness

Excitability

Headache

Irritability

Strange or unusual behaviour

Tingling

Unreliable memory

Unsteadiness when walking

Visual field constriction, likely to be irreversible

Weight gain